NINDS-RFQ-25-006113

During this ancillary workshop, NINDS will provide data on PRECISE-TBI tools that support effective data curation, standardization, and reuse. This workshop builds on the newly launched NT-PRECEDS initiative, which supports the development and harmonization of preclinical Common Data Elements (CDEs) across TBI, PTE, and SCI research. Attendees will hear updates from working groups, learn about the NeuroTrauma Common Core CDEs, and explore practical tools and best practices for implementing rigor, reproducibility, and FAIR data principles using a common data model. 

This proposed workshop is designed to build on ongoing efforts at NINDS as well as interagency partnerships and community stakeholders. NINDS has launched the NeuroTrauma PREclinical CDE & Data Standard (NT-PRECEDS) in January 2025. NT-PRECEDS at NINDS is a parallel and complimentary effort with interagency partners funding FITBIR, and PRECISE-TBI. The primary focus and overall goal is to provide support for the development, curation, and harmonization of preclinical CDEs for three Neurotrauma projects: Traumatic Brain Injury (TBI), Post-Traumatic Epilepsy (PTE), and Spinal Cord Injury (SCI). The effort will be led by Hibah Awwad who will oversee the management and progress of the program and will coordinate with the NINDS preclinical CDE leads and NIH staff involved in all 3 projects. The goal of NT-PRECEDS program at NINDS will be achieved via 4 objectives: 1) Developing, curating and harmonizing preclinical CDEs for 3 Neurotrauma projects: Traumatic Brain Injury (TBI), Post Traumatic Epilepsy (PTE) and Spinal Cord Injury (SCI) projects. 2) Developing a set of “core” preclinical CDEs and metadata CDEs harmonized across all 3 neurotrauma preclinical projects, to become the NIH-endorsed preclinical CDEs that will be cataloged in the NLM NIH-endorsed CDE repository. 3) Developing semi-automated tools that will facilitate the use of preclinical CDEs by researchers for data collection, data analysis, data reporting and data sharing. The program will initially address one of the challenges by supporting data scientists to develop a tool to transform raw datasets and map them to Data elements (DE). This will include the ability to browse, identify and select DEs & CDEs before starting their project. This will address the initial barrier of utilization of CDEs by making this API interface user-friendly and making CDEs findable and interoperable; especially for preclinical researchers that are new to data science and data sharing. 4) Dissemination of progress and updates on preclinical CDEs & data standards to preclinical investigators: Discussions/Conversations with preclinical research scientists related to topics that include current data standards, rigor & reproducibility (ARRIVE guidelines), data harmonization, using CDEs to collect data, analyze data and publish data, share data in various repositories, relevance to clinical CDEs. This will occur through a variety of methods including, but not limited to webinar series, presentations at national meetings, tutorial documents & recorded videos shared to an NINDS-public facing website.